Recombinant Human FGF R1α (IIIb)

Fibroblast growth factor receptor-1 alpha (FGFR1-alpha) is an isoform of FGFR1 which is a receptor tyrosine kinase. FGFR1-alpha is expressed in prostate luminal epithelial cells.¹ FGFR1alpha signals are posteriorizing factors that control node regression and posterior embryonic development.²

FGFR1-alpha is a splice variant of FGFR1 containing the first immunoglobulin-like domain, whereas FGFR1-beta lacks this domain.² The presence or absence of this N-terminal domain influences the affinity of the receptor towards aFGF and heparin.³

FGFR1-alpha is expressed in prostate luminal epithelial cells, whereas FGFR1-beta is expressed in basal epithelial cells and smooth muscle cells.

Fc Fusion Protein

rpsptlpeq aqpwgapvev esflvhpgdl lqlrcrlrdd vqsinwlrdg vqlaesnrtr itgeevevqd svpadsglya cvtsspsgsd ttyfsvnvsd alpssedddd dddssseeke tdntkpnpva pywtspekme kklhavpaak tvkfkcpssg tpnptlrwlk ngkefkpdhr iggykvryat wsiimdsvvp sdkgnytciv eneygsinht yqldvversp hrpilqaglp anktvalgsn vefmckvysd pqphiqwlkh ievngskigp dnlpyvqilk hsginssdae vltlfnvtea qsgeyvckvs nyigeanqsa wltvtrpale erpavmtspl yleiegrdmd pkscdkthtc ppcpapellg gpsvflfppk pkdtlmisrt pevtcvvvdv shedpevkfn wyvdgvevhn aktkpreeqy nstyrvvsvl tvlhqdwlng keykckvsnk alpapiekti skakgqprep qvytlppsrd eltknqvslt clvkgfypsd iavewesngq pennykttpp vldsdgsffl yskltvdksr wqqgnvfscs vmhealhnhy tqkslslspg k

Arg22

Lyophilized

The predicted molecular weight of Recombinant Human FGF R1α (IIIb) is Mr 66 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 110-120 kDa.

66

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Moscatelli, D. et al. (2007) Prostate 67: 115
2. Deng, CX. et al. (1999) Dev Biol. 208: 293