Recombinant Human GDF-15 – D-variant
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BackgroundGrowth and Differentiation Factor 15 (GDF-15) is a member of the TGF-β Superfamily and also a member of the subfamily of Growth Differentiation Factors (GDFs) which play important roles in development. GDF-15 has a role in regulating inflammatory and apoptotic pathways during tissue injury and certain disease processes. Protein DetailsEndotoxin Level <0.1 EU/µg as determined by the LAL method Biological Activity The biological activity of Human GDF-15-D was determined by the inhibition of DU-145 cells. The expected ED<sub>50</sub>= 1-2µg/ml. Protein Accession No. Amino Acid Sequence MARNGDDCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI State of Matter Lyophilized Predicted Molecular Mass The predicted molecular weight of Recombinant Human GDF-15-D is Mr 26.8 kDa. Predicted Molecular Mass 26.8 Storage and Stability The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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