Recombinant Human IGF-II

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Pricing & Details

Product. No.I-181
Alternate Names
Insulin-Like Growth Factor II, Somatamedin A, Somatomedin C, C11orf43, FLJ22066, FLJ44734, INSIGF, pp9974
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-181-50 µg
50 µg
$189.00
In stock
Max:
Min: 1
Step: 1
I-181-250 µg
250 µg
$689.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Background

Insulin-like growth factor 2 (IGF-2) is a polypeptide hormone with structural and functional homology with IGF-I and pro-insulin.1 IGF-2 exerts its effects by binding to the IGF-1 receptor. IGF2 may also bind to the IGF-2 receptor. The major role of IGF2 is growth promoting hormone during gestation. IGF-2 has been shown to be an important regulator of fetoplacental growth.2

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human IGF-II was determined by a serum-free cell proliferation assay using the human cell line MCF-7 (Karey, K.P. et al., Cancer Research, 1988, 48:4083). The expected ED50 for this effect is typically 1.5 – 6 ng/ml.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
ayrpset lcggelvdtl qfvcgdrgfy fsrpasrvsr rsrgiveecc frscdlalle tycatpakse
N-terminal Sequence Analysis
Ala25
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IGF-II is Mr 7.5 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is 7 kDa (reducing conditions).
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from a sterile solution of 0.1M acetic acid.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Hoeflich, A. et al. (1994) Hormone Research 41: 66
2. Gruslin, A. et al. (2005) The National Acad. of Sci.
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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