Anti-Human IGF-II (Clone 75015)

Pricing & Details

Product No.I-650
Clone
75015
Protein
IGF-II
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Insulin-Like Growth Factor II, Somatamedin A, Somatomedin C, C11orf43, FLJ22066, FLJ44734, INSIGF, pp9974
Isotype
Mouse
IgG1
Applications
N
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-650-25 µg
25 µg
$195.00
In stock
Max:
Min: 1
Step: 1
I-650-100 µg
100 µg
$430.00
In stock
Max:
Min: 1
Step: 1
I-650-500 µg
500 µg
$935.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Immunogen
Purified Recombinant Human IGF-II (Accession # P01344.1)
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Formulation
This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Storage and Handling
The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Country of Origin
USA
Shipping
Next Day Ambient
Other Applications Reported In Literature ?
Neutralization: This antibody is useful for neutralization of Human IGF-II bioactivity. The antibody dose required to neutralize 50% (ND50) of the biological activity of Human IGF-II (at 14 ng/ml) is 10-30 µg/ml.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human insulin-like growth factor II (IGF-II) (Clone 75015) recognizes an epitope on Human IGF-II. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody shows 100% cross-reactivity with rmIGF-II and no cross-reactivity with rhIGF-I or rmIGF-I.
Background
Insulin-like growth factor 2 (IGF-2) is a polypeptide hormone with structural and functional homology with IGF-I and pro-insulin.1 IGF-2 exerts its effects by binding to the IGF-1 receptor. IGF2 may also bind to the IGF-2 receptor. The major role of IGF2 is growth promoting hormone during gestation. IGF-2 has been shown to be an important regulator of fetoplacental growth.2

Antigen Details

Protein
PubMed

References & Citations

1. Hoeflich, A. et al. (1994) Hormone Research 41: 66
2. Gruslin, A. et al. (2005) The National Acad. of Sci.

Formats Available

Prod No.
Description
I-650
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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