Recombinant Human IGFBP-4
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BackgroundInsulin-like growth factor binding protein 4, also known as IGFBP4, is a member of the insulin-like growth factor binding protein (IGFBP) family that are cysteine-rich proteins that act as a carrier protein. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. The protein itself does not prevent the formation of cancer.1 However it may reduce the growth of cancer and act as an apoptotic factor. Protein DetailsPurity >97% by SDS-PAGE and analyzed by silver stain. Endotoxin Level <0.01 EU/µg as determined by the LAL method Protein Accession No. Amino Acid Sequence mdeaihcppc seeklarcrp pvgceelvre pgcgccatca lglgmpcgvy tprcgsglrc ypprgvekpl htlmhgqgvc melaeieaiq eslqpsdkde gdhpnnsfsp csahdrrclq khfakirdrs tsggkmkvng apredarpvp qgscqselhr alerlaasqs rthedlyiip ipncdrngnf hpkqchpald gqrgkcwcvd rktgvklpgg lepkgeldch qladsfre
N-terminal Sequence Analysis Met State of Matter Lyophilized Predicted Molecular Mass The predicted molecular weight of Recombinant Human IGFBP-4 is Mr 26 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 32 kDa. Predicted Molecular Mass 26 Formulation This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank References & Citations1. Winslet, MC. et al. (2007) Human Reproduction 5: 128 IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.