Recombinant Human IL-21R

Interleukin 21 receptor is a cytokine receptor for interleukin 21 (IL21) and both proteins play an important role in the regulation of the immune system. A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21 . The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family.1,2 IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling.3,4 Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.

The biological activity of Human IL-21 R was determined by is ability to inhibit IL-21. The expected ED₅₀=10 - 25µg/ml in the presence of 125ng/ml or human IL-21.

Fc Fusion Protein

c pdlvcytdyl qtvicilemw nlhpstltlt wqdqyeelkd eatscslhrs ahnathatyt chmdvfhfma ddifsvnitd qsgnysqecg sfllaesikp appfnvtvtf sgqyniswrs dyedpafyml kgklqyelqy rnrgdpwavs prrklisvds rsvsllplef rkdssyelqv ragpmpgssy qgtwsewsdp vifqtqseel kegwnp (DIEGRMD)(Human IgG₁)

Cys20

Lyophilized

The predicted molecular weight of Recombinant Human IL-21 R is Mr 51.7 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 80-85 kDa.

51.7

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient