Recombinant Human IL-22

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Pricing & Details

Product. No.I-230
Alternate Names
ZcytoR11, CRF2-9, IL-TIF
Expression Host
E. coli
Prod No.
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I-230-10 µg
10 µg
In stock
Min: 1
Step: 1
I-230-100 µg
100 µg
In stock
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Step: 1
I-230-500 µg
500 µg
In stock
Min: 1
Step: 1
I-230-1 mg
1 mg
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Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.


IL (interleukin)-22 is an IL-10 homologue, produced by activated T cells that binds to and signals via the class II cytokine receptor (R) heterodimer IL-22RA1/CFR2-4 (IL-10R2).1 IL-22 regulates the production of acute phase proteins of the immunological response. On binding to its cognate receptor (IL-22R1), which is associated to the interleukin-10 receptor 2, IL-22 promotes activation of signal transducer and activator of transcription (STAT) pathway and several other cellular responses.2 IL-22 plays an important role in skin inflammatory processes and wound healing.3

Protein Details

>95% by SDS Page and analyzed by silver stain.
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human IL-22 was determined by its ability to induce IL-10 secretion in Colo205 cells (Nagalakshmi, M.L. et al., 2004, International Immunopharmacology. 4:679-691 The expected ED50 for this effect is typically 60-300 pg/mL.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
The DNA sequence encoding the mature human IL-22 protein sequence (Ala 34 - Ile 179) was inserted into a suitable expression vector and was expressed in E coli (Dumoutier, L. et al., 2000, PNAS 97:10144).
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-22 is Mr 16.5 kDa.
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Yssel, H. et al.(2002) Int. Immunol. 14: 1351
2. Polikarpov, I. et al. (2006) Vitam Horm. 74: 77
3. Morel, F. et al. (2005) J. Immunol. 174: 3695
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Prod No.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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