Recombinant Human IL-29

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Pricing & Details

Prod. No.I-376
Expression Host
NS0 cells
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25 µg
Min: 1
Step: 1


Interleukin-29 (IL-29), also known as IFN-λ1, is a cytokine distantly related to type I interferons and the IL-10 family. It exerts its biological effects through a receptor that also binds IL-28A and IL-28B.2 This receptor is a heterodimeric class II cytokine receptor that consists of IL-10RB and IL-28RA. IL-29 activities overlap those of type I IFNs and include anti-viral activity and up-regulation of MHC class I antigen expression.3 The expression of IL-29 is induced by virus infection or double-stranded RNA. Upon binding to the receptor, it also induces JAK kinase activation and phosphorylation of STAT and STAT2.4 IL-28 and IL-29 have recently been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells.5

Protein Details

>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human IFN-λ1 was determined in an anti-viral assay using human HepG2 cells infected with encephalomyocarditis.1 The expected ED50 for this effect is typically 1 - 5 ng/ml.
Fusion Protein Tag
Histidine Tag
Expression Host
NS0 cells
Protein Accession No.
Amino Acid Sequence
g pvptskpttt gkgchigrfk slspqelasf kkardalees lklknwscss pvfpgnwdlr llqvrerpva leaelaltlk vleaaagpal edvldqplht lhhilsqlqa ciqpqptagp rprgrlhhwl hrlqeapkke sagcleasvt fnlfrlltrd lkyvadgnlc lrtsthpest hhhhhhhhhh
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-29 is Mr 21.4 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 26-35 kDa.
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Sheppard, P. et al. (2003) Nat Immunol. 4(1):63-8.
2. Zitzmann, K. et al. (2006) Biochem. Biophys. Research Commun. 344:1334
3. Kotenko, SV. et al. (2003) Nat. Immunol. 4:69
4. Maher, SG. et al. (2008) Cancer Biol. Ther. 7:1109
5. Mennechet, F. et al. (2006) Immunobiology 107:4417
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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