Recombinant Human MIF

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Pricing & Details

M1320
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
Add to cart
M1320-25 µg
25 µg
$225.00
In stock
Max:
Min: 1
Step: 1
M1320-100 µg
100 µg
$495.00
In stock
Max:
Min: 1
Step: 1
M1320-500 µg
500 µg
$1,950.00
In stock
Max:
Min: 1
Step: 1
M1320-1 mg
1 mg
$3,215.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Background

Macrophage migration inhibiting factor (MIF) is a pleiotropic protein that is the key mediator of the innate immune system and plays a crucial role in the host response to bacterial infections.1 MIF acts as a proinflammatory cytokine, a pituitary hormone, and a cell proliferation and migration factor.2 MIF plays a critical role in pathogenesis of ultraviolet-B (UVB)-induced nonmelanoma skin cancer (NMSC).3

Protein Details

Purity
>95% by SDS-PAGE and HPLC
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The activity is determined by the dose-dependent induction of IL-8 from human PBMCs and is typically less than 50.0 ng/mL. This corresponds to an expected specific activity of 2 x 104 units/mg.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
MPMFIVNTNV PRASVPDGFL SELTQQLAQA TGKPPQYIAV HVVPDQLMAF GGSSEPCALC SLHSIGKIGG AQNRSYSKLL CGLLAERLRI SPDRVYINYY DMNAANVGWN NSTFA
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human MIF is Mr 12.5 kDa.
Formulation
Lyophilized from a sterile filtered aqueous solution containing 10 mM Trisodium phosphate (Na3PO4), pH 7.5.
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C - -70°C. The reconstituted protein can be stored for at least four (4) weeks at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Pascal, RA. et al. (2005) Infec. Immun 73: 3783
2. Yamazaki, M. et al. (2009) Acta Neuropathol. 117: 321
3. Vanbuskirk, AM. et al. (2008) FASEB J.
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Prod No.
Description
M1320
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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