Recombinant Human Neuroserpin

Lyophilized

The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Next Day Ambient

MTGATFPEEA IADLSVNMYN RLRATGEDEN ILFSPLSIAL AMGMMELGAQ GSTQKEIRHS MGYDSLKNGE EFSFLKEFSN MVTAKESQYV MKIANSLFVQ NGFHVNEEFL QMMKKYFNAA VNHVDFSQNV AVANYINKWV ENNTNNLVKD LVSPRDFDAA TYLALINAVY FKGNWKSQFR PENTRTFSFT KDDESEVQIP MMYQQGEFYY GEFSDGSNEA GGIYQVLEIP YEGDEISMML VLSRQEVPLA TLEPLVKAQL VEEWANSVKK QKVEVYLPRF TVEQEIDLKD VLKALGITEI FIKDANLTGL SDNKEIFLSK AIHKSFLEVN EEGSEAAAVS GMIAISRMAV LYPQVIVDHP FFFLIRNRRT GTILFMGRVM HPETMNTSGH DFEEL

Neuroserpin is an axonally secreted serine proteinase inhibitor that is expressed in neurons during embryogenesis and in the adult nervous system¹ and is implicated in the regulation of proteases involved in processes such as synaptic plasticity, neuronal migration and axogenesis.² Neuroserpin plays a neuroprotective role, by blocking the deleterious effects of proteolytic enzymes such as tissue plasminogen activator (tPA). A familial form of a neurodegenerative disease, termed familial encephalopathy with neuroserpin inclusion bodies, is caused by the intracellular polymerization and accumulation of mutated neuroserpin, leading to neuronal death and dementia.³

1. Sonderegger, P. et al. (1998) Ame Society of Biochem. Molec. Biol. 273: 2312
2. Birch, NP. et al. (2002) J Neurochem. 80: 1406
3. Sonderegger, P. et al. (2006) Front Bioscie. 11: 33