Recombinant Human Oncostatin M

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Pricing & Details

Product. No.O101
Alternate Names
Oncostatin M, MGC20461
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
Add to cart
O101-10 µg
10 µg
$219.00
In stock
Max:
Min: 1
Step: 1
O101-50 µg
50 µg
$869.00
In stock
Max:
Min: 1
Step: 1
O101-1 mg
1 mg
$5,649.00
In stock
Max:
Min: 1
Step: 1

Background

Oncostatin M (OSM) is a pleitropic cytokine produced by activated T lymphocytes and monocytes that is structurally and functionally related to the subfamily of cytokines known as the IL-6-type cytokine family.1 OSM either inhibits or enhances the growth of cells depending on cell type. It inhibits proliferation of skeletal muscle cells by blocking cell cycle progression from G(1) to S phase.2 OSM is also a key mediator for proliferation and anti-apoptosis of hepatocytes which suggests that OSM gene therapy is useful, as preventive and curative means, for the treatment of patients with liver damage.3

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human OSM was measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1 (Kitamura, T. et al., 1989, J. Cell Physiol. 140:323-334). The expected ED50 for this effect is typically 0.15 - 0.3 ng/ml.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
aaigscskey rvllgqlqkq tdlmqdtsrl ldpyiriqgl dvpklrehcr erpgafpsee tlrglgrrgf lqtlnatlgc vlhrladleq rlpkaqdler sglniedlek lqmarpnilg lrnniycmaq lldnsdtaep tkagrgasqp ptptpasdaf qrklegcrfl hgyhrfmhsv grvfskwges pnrsrr
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human OSM is Mr 22 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Gómez-Lechón, MJ. et al. (1999) Life Sci. 65: 2019
2. Jo, SA. et al. (2008) Cell Signal 20: 120
3. Tsujimura, T. et al. (2007) Am J Pathol. 171: 872
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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