Recombinant Human TRAIL R1

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Pricing & Details

Product. No.T217
Alternate Names
TNFRSF10A, APO2, CD261, DR4, MGC9365
Expression Host
Sf 21 Insect Cells
Species
Human
Prod No.
Size
Price
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T217-100 µg
100 µg
$379.00
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Min: 1
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Background

Tumor necrosis factor-related apoptosis-inducing ligand Receptor 1 (TRAIL-R1) is a cell-surface receptor involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell-death signaling.1 The death ligand TRAIL bears high potential as a new anticancer agent, as binding to the death receptors TRAIL-R1 or TRAIL-R2 triggers apoptosis in most cancer cells.2

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human TNF-Related Apoptosis Inducing Ligand Receptor-1 is determined by its inhibitory effect of IL-8 production in human PBMC by human TRAIL/Apo2L. 95% inhibition (100 ng/ml of TRAIL/Apo2L) was reached using a concentration of 100 ng/ml of TRAIL Receptor-1.
Fusion Protein Tag
Fc Fusion Protein
Expression Host
Sf 21 Insect Cells
Protein Accession No.
Amino Acid Sequence
(a)t iklhdqsigt qqwehsplge lcppgshrse rpgacnrcte gvgytnasnn lfaclpctac ksdeeerspc tttrntacqc kpgtfrndns aemcrkcstg cprgmvkvkd ctpwsdiecv hkesgnghni egrmdpkscd kthtcppcpa pellggpsvf lfppkpkdtl misrtpevtc vvvdvshedp evkfnwyvdg vevhnaktkp reeqynstyr vvsvltvlhq dwlngkeykc kvsnkalpap iektiskakg qprepqvytl ppsrdeltkn qvsltclvkg fypsdiavew esngqpenny kttppvldsd gsfflysklt vdksrwqqgn vfscsvmhea lhnhytqksl slspgkhhhh hh
N-terminal Sequence Analysis
Ala109 & Thr110
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human TRAIL R-1 is Mr 43 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 46 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Yoo, NJ. et al. (2001) Oncogene 20: 399
2. Eberle, J. et al. (2005) J Investigative Dermatol. 125: 1010
3. Rimm, D. et al. (2005) Clin Cancer Research 11
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Prod No.
Description
T217
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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