Recombinant Human TRAIL R2

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Pricing & Details

Product. No.T218
Alternate Names
TNFRSF10B, CD262, DR5, KILLER, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
Expression Host
CHO
Species
Human
Prod No.
Size
Price
Avail.
Qty
Add to cart
T218-100 µg
100 µg
$369.00
In stock
Max:
Min: 1
Step: 1

Background

Tumor necrosis factor-related apoptosis-inducing ligand Receptor 2 (TRAIL-R2) is a cell-surface receptor involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell-death signaling.1 The death ligand TRAIL bears high potential as a new anticancer agent, as binding to the death receptors TRAIL-R1 or TRAIL-R2 triggers apoptosis in most cancer cells.2 TRAIL-R2 has been shown to be associated with a decrease in the survival rates of breast cancer patients.3

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L‑929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 0.7-2 ng/mL.
Fusion Protein Tag
Fc Fusion Protein
Expression Host
CHO
Protein Accession No.
Q6FH58
Amino Acid Sequence
alitqqd lapqqraapq qkrsspsegl cppghhised grdcisckyg qdysthwndl lfclrctrcd sgevelspct ttrntvcqce egtfreedsp emcrkcrtgc prgmvkvgdc tpwsdiecvh keiegrmdpk scdkthtcpp cpapellggp svflfppkpk dtlmisrtpe vtcvvvdvsh edpevkfnwy vdgvevhnak tkpreeqyns tyrvvsvltv lhqdwlngke ykckvsnkal papiektisk akgqprepqv ytlppsrdel tknqvsltcl vkgfypsdia vewesngqpe nnykttppvl dsdgsfflys kltvdksrwq qgnvfscsvm healhnhytq kslslspgkh hhhhh
N-terminal Sequence Analysis
Ala54
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human TRAIL Receptor-2 is Mr 42 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 54-61 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Yoo, NJ. et al. (2001) Oncogene 20: 399
2. Eberle, J. et al. (2005) J Investigative Dermatol. 125: 1010
3. Burtness, BA. et al. (2005) Clin Cancer Research 11(16):5856-62.
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Prod No.
Description
T218
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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