Recombinant Human TRAIL R4

Recombinant Human TRAIL R4

Product No.: T403

[product_table name="All Top" skus="T403"]

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Alternate Names
TNF-Related Apoptosis-Inducing Ligand Receptor 4, TNFRSF10D, Decoy Receptor 2 (DCR2), CD264, TRUNDD, TR4
Product Type
Recombinant Protein
Expression Host
NS0 Cells

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Select Product Size
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TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4) is a decoy receptor that negatively regulate TRAIL-induced cytotoxicity by competing for ligand binding with TRAIL-R1 and TRAIL-R2.1 TRAIL R4 is expressed mainly on CD8+ and NK cells and induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4 contains partially truncated death domain and therefore is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing.1,2

Protein Details

>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01 EU/µg as determined by the LAL method
Protein Accession No.
Amino Acid Sequence
atipr qdevpqqtva pqqqrrslke eecpagshrs eytgacnpct egvdytiasn nlpscllctv cksgqtnkss ctttrdtvcq cekgsfqdkn spemcrtcrt gcprgmvkvs nctprsdikc knesaasstg ktpaaeetvt tilgmlaspy hiegridpks cdkthtcppc papellggps vflfppkpkd tlmisrtpev tcvvvdvshe dpevkfnwyv dgvevhnakt kpreeqynst yrvvsvltvl hqdwlngkey kckvsnkalp apiektiska kgqprepqvy tlppsrdelt knqvsltclv kgfypsdiav ewesngqpen nykttppvld sdgsfflysk ltvdksrwqq gnvfscsvmh ealhnhytqk slslspgkhh hhhh
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human TRAIL R4 is Mr 44.2 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 70-80 kDa.
Predicted Molecular Mass
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Chan, FK. et al. (2005) Proc Natl Acad Sci USA 102: 18099
2. Sanlioglu, S. et al. (2005) BMC Cancer 5: 54
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.