Recombinant Mouse CD62E

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Pricing & Details

Product. No.E211
Alternate Names
E-Selectin, SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2
Expression Host
NS0 cells
Species
Mouse
Prod No.
Size
Price
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E211-100 µg
100 µg
$359.00
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Background

E-selectin, also known as CD62E is an inducible leukocyte adhesion glycoprotein specifically expressed by endothelial cells.1 E-selectin helps initiate recruitment of circulating leukocytes to cutaneous, bone and inflamed tissues.2 E-selectin is found in inflammatory skin lesions in psoriasis, contact dermatitis, and delayed- type hypersensitivity, in arthritic joints, and in heart and renal allografts undergoing rejection.3 E-selectin-targeting antibody drug conjugate has potential as a prostate cancer therapy.4

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Biological Activity
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 104 cells/well are added to mouse E Selectin coated plates (2 μg/ml with 100 μl/well), approximately 85 - 100% will adhere.
Fusion Protein Tag
Fc Fusion Protein
Expression Host
NS0 cells
Protein Accession No.
Amino Acid Sequence
wyynasselm tydeasaycq rdythlvaiq nkeeinylns nlkhspsyyw igirkvnnvw iwvgtgkplt eeaqnwapge pnnkqrnedc veiyiqrtkd sgmwndercn kkklalcyta sctnascsgh gecietinsy tckchpgflg pnceqavtck pqehpdygsl ncshpfgpfs ynsscsfgck rgylpssmet tvrctssgew sapapachvv ecealthpah girkcssnpg sypwnttctf dcvegyrrvg aqnlqctssg iwdnetpsck avtcdaipqp qngfvscshs tagelafkss cnftceqsft lqgpaqvecs aqgqwtpqip vckavqceal sapqqgnmkc lpsasgpfqn gsscefscee gfelkgsrrl qcgprgewds kkptcsavkc ddvprpqngv mecahattge ftyksscafq cnegfslhgs aqlectsqgk wtqevpscqv vqcpsldvpg kmnmscsgta vfgtvceftc pddwtlngsa vltcgatgrw sgmpptceap vsptrpiegr mdpkscdkth tcppcpapel lggpsvflfp pkpkdtlmis rtpevtcvvv dvshedpevk fnwyvdgvev hnaktkpree qynstyrvvs vltvlhqdwl ngkeykckvs nkalpapiek tiskakgqpr epqvytlpps rdeltknqvs ltclvkgfyp sdiavewesn gqpennyktt ppvldsdgsf flyskltvdk srwqqgnvfs csvmhealhn hytqkslsls pgkhhhhhh
N-terminal Sequence Analysis
Trp22
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse E-Selectin is Mr 85.8 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 110-130 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Milstone, D. et al. (2004) PNAS 101: 8005
2. Dimitroff, CJ. et al. (2009) J Visualized Experiments
3. Hirata, T. et al. (2005) J Immunol. 175: 8042
4. Vanitha, R. et al. (2003) Cancer Res. 63: 6387
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Prod No.
Description
E270
E211
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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