Recombinant Mouse DCC

Deleted in Colorectal Carcinoma, also known as DCC is a tumor suppressor gene found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine.¹ DCC may participate in signaling pathways that regulate cell proliferation and/or differentiation, two cellular processes that often go awry during tumorigenesis.² DCC is required for the formation of major axonal projections by embryonic cortical neurons, including the corpus callosum, hippocampal commissure, and cortico-thalamic tracts.³

Fc Fusion Protein

fqikpftsl hfvsepsdav tmrggnvlln csaesdrgvp vikwkkdgli lalgmddrkq qlpngslliq nilhsrhhkp deglyqceas ladsgsiisr takvtvagpl rflsqtesit afmgdtvllk cevigepmpt ihwqknqqdl nplpgdsrvv vlpsgalqis rlqpgdsgvy rcsarnpasi rtgneaevri lsdpglhrql yflqrpsnvi aiegkdavle ccvsgyppps ftwlrgeevi qlrskkysll ggsnllisnv tdddsgtytc vvtyknenis asaeltvlvp pwflnhpsnl yayesmdief ecavsgkpvp tvnwmkngdv vipsdyfqiv aipsssilps aprdvlpvlv ssrfvrlswr ppaeakgniq tftvffsreg dnreralntt qpgslqltvg nlkpeamytf rvvaynewgp gessqpikva tqpelqvpgp venlhavsts ptsilitwep payangpvqg yrlfctevst gkeqnievdg lsykleglkk fteytlrfla ynrygpgvst dditvvtlsd vpsappqnis levvnsrsik vswlpppsgt qngfitgyki rhrkttrrge metlepnnlw ylftglekgs qysfqvsamt vngtgppsnw ytaetpendl desqvpdqps slhvrpqtnc iimswtppln pnivvrgyii gygvgspyae tvrvdskqry ysierlesss hyvislkafn nagegvplye sattrsitdp tdpvdyypll ddfptsgpdv stpmlppvgv qavaltheav rvswadnsvp knqktsdvrl ytvrwrtsfs asakyksedt tslsytatgl kpntmyefsv mvtknrrsst wsmtahatty eaaptsapkd ltvitregkp ravivswqpp leangkitay ilfytldkni piddwimeti sgdrlthqim dlsldtmyyf riqarnvkgv gplsdpilfr tlkvehpdkm andqgrhgdg gywpvdtnli drstlneppi gqmhpphgsv tpqknsndie grmdpkscdk thtcppcpap ellggpsvfl fppkpkdtlm isrtpevtcv vvdvshedpe vkfnwyvdgv evhnaktkpr eeqynstyrv vsvltvlhqd wlngkeykck vsnkalpapi ektiskakgq prepqvytlp psrdeltknq vsltclvkgf ypsdiavewe sngqpennyk ttppvldsdg sfflyskltv dksrwqqgnv fscsvmheal hnhytqksls lspgkhhhhh h

Phe32

Lyophilized

The predicted molecular weight of Recombinant Mouse DCC is Mr 146 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 160-170 kDa.

146

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Vogelstein, B. et al. (1994) Genes Dev. 8: 1174
2. Fearon, ER. et al. (1995) Curr Opin Genet Dev. 5: 72
3. Kennedy, TE. et al. (2008) J Neurochem. 107: 398