Recombinant Mouse Flt-3

Fms-Like tyrosine kinase 3 (FLT3) is a member of the class III tyrosine kinase receptor family, normally expressed in hematopoietic, immune and neural systems.¹ FLT3 is expressed in various lymphohematopoietic cells and tissues, including a series of immature cell lines and leukemias of lymphocytic origin.² FLT3 is a promising target for the therapeutic intervention for acute leukemias, particularly acute myeloid leukemia (AML) which are severe and aggressive malignancy.¹

Fc Fusion Protein

nqd lpvikcvlis henngssagk pssyrmvrgs pedlqctprr qsegtvyeaa tvevaesgsi tlqvqlatpg dlsclwvfkh sslgcqphfd lqnrgivsma ilnvtetqag eyllhiqser anytvlftvn vrdtqlyvlr rpyfrkmenq dallcisegv peptvewvlc sshresckee gpavvrkeek vlhelfgtdi rccarnalgr ectklftidl nqapqstlpq lflkvgeplw irckaihvnh gfgltweled kaleegsyfe mstystnrtm irillafvss vgrndtgyyt cssskhpsqs alvtilekgf inatssqeey eidpyekfcf svrfkaypri rctwifsqas fpceqrgled gysiskfcdh knkpgeyify aenddaqftk mftlnirkkp qvlanasasq ascssdgypl pswtwkkcsd kspncteeip egvwnkkanr kvfgqwvsss tlnmseagkg llvkccayns mgtscetifl nspgpfpfiq dnisiegrmd pkscdkthtc ppcpapellg gpsvflfppk pkdtlmisrt pevtcvvvdv shedpevkfn wyvdgvevhn aktkpreeqy nstyrvvsvl tvlhqdwlng keykckvsnk alpapiekti skakgqprep qvytlppsrd eltknqvslt clvkgfypsd iavewesngq pennykttpp vldsdgsffl yskltvdksr wqqgnvfscs vmhealhnhy tqkslslspg khhhhhh

Asn28

Lyophilized

The predicted molecular weight of Recombinant Mouse Flt-3 is Mr 85 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 116 kDa.

85

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Botta, M. et al. (2008) Curr Med Chem. 15: 3113
2. Birnbaum, D. et al. (1993) Blood 82: 1110