Recombinant Mouse Gas6

Recombinant Mouse Gas6

Product No.: G655

[product_table name="All Top" skus="G655"]

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Alternate Names
Growth Arrest Specific 6, AXLLG, AXSF, DKFZp666G247, FLJ34709
Product Type
Recombinant Protein
Expression Host
NS0 Cells

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Growth arrest-specific 6, also known as GAS6 is a growth factor1 that serves as a ligand for members of the Axl subfamily of receptor protein-tyrosine kinases.2 GAS6 is expressed in hematopoietic tissue.3 GAS6 function as a direct regulator of osteoclastic function; they give an insight into the role of these vitamin K-dependent ligands in bone resorption in vivo.2 GAS6 has a potential therapeutic target to minimize graft-versus-host disease (GVHD).4

Protein Details

>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Mouse Gas6 was determined by its ability to bind rmAxl/Fc in a functional ELISA. Immobilized rmAxl/Fc at 2 μg/ml (100 μl/well) can bind rmGas6 with a linear range of 0.08 - 5 ng/ml.
Fusion Protein Tag
Histidine Tag
Protein Accession No.
Amino Acid Sequence
dqctpnpcdk kgthicqdlm gnffcvctdg wggrlcdkdv necvqknggc sqvchnkpgs fqcachsgfs lasdgqtcqd idectdsdtc gdarcknlpg sysclcdegy tysskektcq dvdecqqdrc eqtcvnspgs ytchcdgrgg lklspdmdtc edilpcvpfs maksvkslyl grmfsgtpvi rlrfkrlqpt rllaefdfrt fdpegvlffa ggrsdstwiv lglragrlel qlryngvgri tssgptinhg mwqtisveel ernlvikvnk davmkiavag elfqlergly hlnltvggip fkeselvqpi nprldgcmrs wnwlngedsa iqetvkantk mqcfsvterg sffpgngfat yrlnytrtsl dvgtettwev kvvarirpat dtgvllalvg dddvvisval vdyhstkklk kqlvvlaved valalmeikv cdsqehtvtv slregeatle vdgtkgqsev staqlqerld tlkthlqgsv htyvgglpev svisapvtaf yrgcmtlevn gkildldtas ykhsditshs cppvehatph hhhhh
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse Gas6 is Mr 62 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 72 kDa (reducing conditions).
Predicted Molecular Mass
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Suda, T. et al. (1998) Stem Cells 16: 229
2. Schneider, C. et al. (2001) Mol Cell Biol. 21: 902
3. Aglietta, M. et al. (1997) Exp Hematol. 25: 1219
4. Angelillo-Scherrer, A. et al. (2005) J Clin Invest. 115(2):237-46.
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.