Recombinant Mouse IL-17E
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BackgroundIL-17E, also known as IL-25, is a novel member of the IL-17 family of cytokines1 and a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses.2 IL-17E has a heterodimeric receptor. The receptor is composed of two subunits IL-17RA and IL-17RB. Although IL-17E only binds IL-17RB directly, both subunit receptors are essential for IL-17E functions. IL-17E induces activation of NF-κB and stimulates production of the proinflammatory chemokine IL-8. 1 IL-17E may contribute to the induction and maintenance of eosinophilic inflammation in the airways by acting on lung fibroblasts and therefore has a role in asthma pathophysiology.3 Protein DetailsPurity >95% by SDS-PAGE and HPLC Endotoxin Level <0.1 EU/µg as determined by the LAL method Protein Accession No. State of Matter Lyophilized Predicted Molecular Mass The molecular weight of Recombinant Mouse IL-17E is Mr 35.5 kDa. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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