Recombinant Mouse IL-20

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Pricing & Details

Product. No.I-526
Alternate Names
Interleukin-20, ZCYTO10, IL10D
Expression Host
E. coli
Species
Mouse
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-526-25 µg
25 µg
$369.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Background

Interleukin-20 (IL-20) is a pleiotropic inflammatory protein belonging to the IL-10 family of cytokines. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells.1 IL-20 plays a critical role in the induction and maintenance of psoriasis.2

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Mouse IL-20 was determined by a cell proliferation assay and The expected ED50=0.5-2.5 ng/ml.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
Leu25 - Leu176 (Accession No.: Q9JKV9.1)
N-terminal Sequence Analysis
Met
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse IL-20 is Mr 17 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from 20mM NaH2PO2 and 20 mM NaCL pH 6.5 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Kupper, TS. et al. (2006) Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chem. 5: 243
2. Dam, TM. et al. (2009) Br J Dermatol. 160: 284
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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