Recombinant Mouse IL-20

Interleukin-20 (IL-20) is a pleiotropic inflammatory protein belonging to the IL-10 family of cytokines. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells.¹ IL-20 plays a critical role in the induction and maintenance of psoriasis.²

The biological activity of Mouse IL-20 was determined by a cell proliferation assay and The expected ED₅₀=0.5-2.5 ng/ml.

Leu25 - Leu176 (Accession No.: Q9JKV9.1)

Met

Lyophilized

The predicted molecular weight of Recombinant Mouse IL-20 is Mr 17 kDa.

17

This recombinant protein was 0.2 µm filtered and lyophilized from 20mM NaH₂PO₂ and 20 mM NaCL pH 6.5 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Kupper, TS. et al. (2006) Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chem. 5: 243
2. Dam, TM. et al. (2009) Br J Dermatol. 160: 284