Interleukin-20 (IL-20) is a pleiotropic inflammatory protein belonging to the IL-10 family of cytokines. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is capable of stimulating colony formation by CD34+ multipotential progenitors but not by other progenitor cells. 1 It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. A specific receptor for this cytokine is expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.2 Human IL-20 is active on mouse cells.
>97% by SDS-PAGE and analyzed by silver stain.
<1.0 EU/µg as determined by the LAL method
Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with human IL-20 Rα and human IL-20 Rβ. The ED50 for this effect is 0.05-0.3 ng/mL.
Protein Accession No.
Amino Acid Sequence
mlktlnl gscviatnlq eirngfsdir gsvqakdgni dirilrrtes lqdtkpanrc cllrhllrly ldrvfknyqt pdhytlrkis slansfltik kdlrlchahm tchcgeeamk kysqilshfe klepqaavvk algeldillq wmeete
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-20 is Mr 17.6 kDa.
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) with BSA as a carrier protein. pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank
References & Citations
1. Kupper, TS. et al. (2006) Anti-Inflamm. & Anti-Allergy Agents Med. Chem. 5:243
2. Dam, TM. et al. (2009) Br. J. Dermatol. 160:284
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.