Recombinant Mouse IL-28A
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BackgroundInterleukin-28A (IL-28A) also known as IFNL2 is a novel cytokine that exerts its biological effects through a receptor that also binds IL28B and IL29. IL28A induces phosphorylation of STAT1, STAT2, and STAT31 IL-28A has antiviral activities and stimulates antiviral responses through a heterodimeric receptor. IL-28A represents a potential novel approach for therapy of Th1-mediated inflammatory diseases such as T-cell-mediated hepatitis.2 Protein DetailsPurity >95% by SDS Page and analyzed by silver stain. Endotoxin Level <1.0 EU/µg as determined by the LAL method Biological Activity The biological activity of Mouse IL-28A was determined its ability to activate STAT following receptor - ligand interaction. Amino Acid Sequence MDPVPRATRL PVEAKDCHIA QFKSLSPKEL QAFKKAKDAI EKRLLEKDMR CSSHLISRAW DLKQLQVQER PKALQAEVAL TLKVWENMTD SALATILGQP LHTLSHIHSQ LQTCTQLQAT AEPKPPSRRL SRWLHRLQEA QSKETPGCLE DSVTSNLFRL LTRDLKCVAS GDQCV State of Matter Lyophilized Predicted Molecular Mass The predicted molecular weight of Recombinant Mouse IL-28A is Mr 20.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 25-30 kDa. Predicted Molecular Mass 20.5 Storage and Stability This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank References & Citations1. Zitzmann K. et al.(2006) Biochem. Biophys. Research Commun. 344: 1334
2. Neurath Markus F. et al.(2007) Gastroenterology 132: 358
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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