Recombinant Mouse Prolactin R

Recombinant Mouse Prolactin R

Product No.: P299

[product_table name="All Top" skus="P299"]

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Alternate Names
Prolactin Receptor, Mammotropin, Luterotropic Hormone, Lutetropin
Product Type
Recombinant Protein
Expression Host
NS0 Cells
Species
Mouse
Applications
ELISA Cap

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Product Size
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Background

Prolactin Receptor (PRLR) is a member of the cytokine receptor superfamily member that lacks an intrinsic kinase domain and relies on the cytoplasmic Jak tyrosine kinases to transduce signals (1). Prolactin receptors have been localized in a number of peripheral tissues, including tissues involved in reproduction (2). It is also expressed both in the stromal and epithelial compartment of the mammary gland (3). Within the immune system, multiple isoforms of the prolactin receptor serve to mediate the effects of its ligand prolactin. These isoforms are structurally and functionally distinct, causing significant differences in ligand affinities, kinetics of transduction and the transduction proteins activated. Differential activation of these pathways may contribute to the pleiotropism of prolactin action in tissues of the immune system (4). Prolactin receptor is required for normal maternal glucose homeostasis during pregnancy (5).

Protein Details

Purity
>90% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Fusion Protein Tag
Fc Fusion Protein
Protein Accession No.
Amino Acid Sequence
sppgkpeihk crspdketft cwwnpgsdgg lptnysltys kegekntyec pdyktsgpns cffskqytsi wkiyiitvna tnemgsstsd plyvdvtyiv epepprnltl evkqlkdkkt ylwvkwlppt itdvktgwft meyeirlkse eadeweihft ghqtqfkvfd lypgqkylvq trckpdhgyw srwgqeksie ipndftlkdd iegrmdpksc dkthtcppcp apellggpsv flfppkpkdt lmisrtpevt cvvvdvshed pevkfnwyvd gvevhnaktk preeqynsty rvvsvltvlh qdwlngkeyk ckvsnkalpa piektiskak gqprepqvyt lppsrdeltk nqvsltclvk gfypsdiave wesngqpenn ykttppvlds dgsfflyskl tvdksrwqqg nvfscsvmhe alhnhytqks lslspgk
N-terminal Sequence Analysis
Ser21
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse PRL is Mr 51 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 60-68 kDa, reducing conditions kDa.
Predicted Molecular Mass
51
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Lindeman, GJ. et al. (2003) J. Biol. Chem. 278:32929
2. Makrigiannakis, A. et al. (2005) Reproductive Biomed. 10:339
3. Talamantes, F. et al. (2001) J. of Endocrinol. 171:85
4. Clevenger, CV. et al. (2001) Lupus. 10:706
5. Mastro, M. et al. (2003) J. Appl. Physiol. 94:518
Elisa Sandwich Protocol
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.