Recombinant Mouse VEGF R1

Vascular endothelial growth factor receptor 1 (VEGF R1), also known as FLT1, is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis.¹ VEGFR1 is mainly expressed in vascular endothelial cells but also in peripheral blood monocytes. VEGFR1 signaling promotes lymphangiogenesis as well as angiogenesis mainly by increasing bone marrow–derived macrophage recruitment.²

Fc Fusion Protein

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Ser27

Lyophilized

The predicted molecular weight of Recombinant Mouse VEGF R1 is Mr 110 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 150-170 kDa.

110

This recombinant protein was 0.2 µm filtered and lyophilized from a solution of 20mM MOPS, 500 mM NaCl and 0.05% CHAPS, pH 7.0.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Ponnambalam, S. et al. (2009) Exp Cell Res. 315(5):877-89.
2. Shibuya, M. et al. (2008) Arteriosclerosis, Thrombosis, and Vascular Biol. 28: 658