Recombinant Rat SCF

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Pricing & Details

Product. No.S498
Alternate Names
KITLG, Steel Factor (SF), DKFZp686F2250, KL-1, Kitl, Mast Cell Growth Factor (MGF)
Expression Host
E. coli
Species
Rat
Prod No.
Size
Price
Avail.
Qty
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S498-10 µg
10 µg
$224.00
In stock
Max:
Min: 1
Step: 1
S498-100 µg
100 µg
$512.00
In stock
Max:
Min: 1
Step: 1
S498-500 µg
500 µg
$1,949.00
In stock
Max:
Min: 1
Step: 1
S498-1 mg
1 mg
$3,214.00
In stock
Max:
Min: 1
Step: 1

Background

Stem cell factor (SCF), otherwise known as KIT ligand or Steel factor1 is a paracrine regulator of germ cell development.2 SCF has the ability to stimulate the growth of hematopoietic progenitor cells and to generate colony-forming cells (CFC) from highly enriched populations of hematopoietic cells.3 SCF is produced by the Sertoli cells and involved in the local regulation of spermatogenesis4 and liver regeneration.5 SCF in conjunction with interleukin-31 may play a significant role in airway remodeling by promoting the recruitment of bone marrow-derived fibroblast precursors into the lung with the capacity to promote lung myofibroblast differentiation.6

Protein Details

Purity
>98% by SDS Page and HPLC
Endotoxin Level
<1.0 EU/µg
Biological Activity
The biological activity of Rat Stem Cell Factor is determined by the dose-dependent stimulation of the proliferation of the human MO7e cell line. The expected ED50 for this effect is 1 x 105 units/mg.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
MQEICRNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV THLSVSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVAC MEENAPKNVK ESLKKPETRN FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA
State of Matter
Lyophilized
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA

References & Citations

1. Toppari, J. et al. (1999) Endocrin 140: 1492
2. Adamson, JW. et al. (1991) PNAS 88: 7420
3. Hervé, L. et al. (2005) J of Endocrin. 186: 131
4. Ramadori, G. et al. (2009) Lab Invest. 89(5):562-74.
6. Phan, SH. et al. (2009) AM J Pathol. 174: 390
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.