TACE (CT) Blocking Peptide

This peptide sequence is located at amino acids 807 to 823 of Human TACE protein.

This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.

Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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TACE (tumor necrosis factor-α-converting enzyme) is a pleiotropic metalloprotease also known as ADAM17 that is found to be constitutively expressed by intestinal epithelial cells.¹ TACE is a major sheddase of TNF-α and its receptors, essential for the generation of soluble, mature molecules.² TACE as a promising target of epidermal growth factor receptor (EGFR) axis inhibition in colorectal cancer (CRC)³ and a principal target for the treatment of TNF-dependent pathologies.⁴

1. Masson D et al. (2009) Int J Mol Med. 23: 41 2. B Chodynicka et al. (2008) J European Acad Dermatol & Venereol. 22: 712 3. Coffey RJ et al. (2008) Clin Cancer Res. 14: 1182 4. Blobel CP et al. (2007) J Immunol. 179: 2689