TL1-A (NT) Blocking Peptide
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Antibody DetailsProduct DetailsReactive Species Human Product Concentration 0.2 mg/ml Amino Acid Location 14 amino acids near the amino terminus of human TL1A. Formulation This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Storage and Handling Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Background TNF-ligand-related molecule 1A (TL1A), is an endothelium-derived T cell costimulator and a ligand for tumor necrosis factor receptor superfamily members DR3 and decoy receptor 3.1 TL1A binds to the death-domain receptor (DR)3 and provides costimulatory signals to activated lymphocytes. Through this interaction, TL1A induces secretion of IFN-γ. Blockade of the TL1A/DR3 pathway may offer therapeutic opportunities in Crohn's disease.2 Antigen DetailsReferences & Citations1. Wei P et al. (2003) J Biol Chem. 278: 39251
2. Fabio Cominelli et al. (2006) PNAS 103: 8441
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