TRAIL R3 (Extracellular Domain – 2) Blocking Peptide

This peptide sequence is located at amino acids 111 to 123 of Human DcR1 protein.

This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.

Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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TNF-related apoptosis-inducing ligand receptor 3 (TRAIL R3) is an antagonist decoy receptor¹ that can inhibit TRAIL-induced apoptosis.² TRAIL R3 is a plasma membrane-bound protein capable of high affinity interaction with the TRAIL ligand.³

1. Fornace AJ Jr. et al. (1999) Oncogene 18: 4153 2. Büchler MW et al. (2001) Anticancer Res. 21: 3153 3. Smith CA et al. (1997) J Exp Med. 186: 1165