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Anti-Mouse CD11a (CD11a) Purified Low Endotoxin Functional Formulation

(LFA-1α)
Monoclonal Antibody


Prod. No.:C376
Clone:I21/7
Isotype:Rat IgG2a
Conc.:0.5 mg/ml
Pkg. Size:0.5 mg, 1.0 mg, 5.0 mg, 25 mg, 100 mg
Starting at:$98.00
Availability:In Stock
Storage:Sterile 2-8°C Detailed storage instructions below.
Description
Specificity:
Rat Anti-Mouse CD11a (Clone I21/7) recognizes the α subunit of the mouse leukocyte function associated antigen-1 (LFA-1). CD11a/CD18αLβ2 leukocyte integrin is a member of a family of heterodimeric receptors which mediate cellular adhesion reactions.1

Antigen Distribution:
The CD11a LFA-1 antigen is present on >97% thymocytes, >95% blood lymphocytes, 79% bone marrow cells and certain lymphoma and macrophage-like cell lines.

Known Species Cross Reactivity: Ms+
Host Species
Rat
Formulation
This antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Purity
>98% by SDS Page and HPLC
Endotoxin
<1.0 EU/µg as determined by the LAL method
Storage and Stability
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
FC, IP, B, FA
Each investigator should determine their own optimal working dilution for specific applications.


Country of Origin
USA
References
1. Trowbridge, I.S. et al. (1981) J. Exp. Med. 154:1517
2. Springer, T. et al. (1982) Immunol. Rev. 68: 171
3. Wuthrich, R. P. et al. (1991) Cell Immunol. 144:22
3. Falanga, P. B. et al. (1991) Eur. J. Immunol. 21: 2259
4. Talento, A. et al. (1993) Transplantation. 55: 418
5. Barret, T.B. et al. (1991) J. Immunol. 146: 1722
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