Anti-8-oxoA DNA/RNA Damage [Clone 6E4]
![Anti-8-oxoA DNA/RNA Damage [Clone 6E4]](https://www.leinco.com/wp-content/uploads/2024/09/High-Res-Cymba-Design-Logo-500x213.png){kind=logo}
Anti-8-oxoA DNA/RNA Damage [Clone 6E4]
Product No.: 12503
Data
Selectivity and Specificity of 6E4 in RNA:* Binds 8-oxoA in single and double stranded RNA
* Recognizes 8-oxoA in RNA base mispairs with standard geometry
Selectivity and Specificity of 6E4 in DNA:* Binds 8-oxoA in single and double stranded DNA
* Recognizes 8-oxoA in all DNA base mispairs
Clone 6E4 8-oxoA Specificity Determined by a competitive inhibition ELISA with nucleoside variants. The % B/Bo is plotted as a function of the concentration (nM) of the indicated competitor. 100% B/Bo indicates no inhibition by the indicated competitor.
- -
- -
Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen 8-OxoA conjugated to KLH Product Concentration Lot Specific Formulation PBS, pH 7.4 State of Matter Liquid Product Preparation Protein G Affinity Chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C to -70°C. Avoid multiple freeze-thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Anti-8-oxoA is a mouse monoclonal antibody targeting oxidative damage in RNA, DNA, ATP and other nucleotide precursors and degradation products. Background This target is a byproduct of oxidative damage to the adenosine nucleobase in DNA, RNA, and nucleotides such as ATP. In DNA, 8-oxoA mispairs may reduce fidelity of replication and cause transcriptional errors by RNA pol II. In RNA, 8-oxoA damage
leads to attenuation of mRNA translation. Specialized base excision repair machinery and nucleotide sanitation processes are present to reduce the mutagenic consequences of 8-oxoA.
This antibody is the intellectual property of CymbaX, sequencing of this antibody is prohibited. Patent Pending Research Area DNA/RNA Damage References & CitationsDaniel J. Tew, Jakob M. Hebert, Brad J. Schmier, Discovery and properties of a monoclonal antibody targeting 8-oxoA, an oxidized adenine lesion in DNA and RNA, Redox Biology 62 (2023) 102658, PMC10074937 Technical Protocols Certificate of Analysis |
Related Products
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
