Anti-Annexin A1 Antibody (90002)

Annexin 1 isolated from human neutrophils.

Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose.

Lyophilized

Purified by Protein A affinity chromatography

This product is stable for at least one (1) year at -20°C to -70°C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles.

Next Day 2-8°C

Mouse Monoclonal Antibody specific to Annexin A1

Annexin 1 belongs to a family of Ca(2+)- dependent phospholipid binding proteins which have molecular weights of approximately 35-40kDa and are localized on the cytosolic face of the plasma membrane. Annexin 1, an endogenous anti-inflammatory protein, has roles in many diverse cellular functions, such as membrane aggregation, inflammation, phagocytosis, proliferation, and apoptosis. Annexin 1 also possesses phosphorylation sites for important proliferative signaling molecules e.g., EGF receptor tyrosine kinase and PKC. This suggests that Annexin 1 may have a role in certain signaling pathways important in cancer. However, the exact mechanisms through which Annexin 1 exerts some or all of its effects are still not clearly understood, and may reveal important functions of Annexin 1 in tumorigenesis and cancer development.

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {UniProtKB:P10107, UniProtKB:P19619, PubMed:17008549, PubMed:19625660, PubMed:2532504, PubMed:2936963, PubMed:8425544, PubMed:8557678}.; [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:22879591, PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {PubMed:15187149, PubMed:22879591, PubMed:25664854}.