Anti-Excitatory Amino Acid Transporter 1 Antibody (90014)

Synthetic peptide derived from the C-terminal domain of rat EAAT1. Accession no. P24942.

Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose, 1mg/ml.

Lyophilized

Purified by Protein A affinity chromatography

This product is stable for at least one (1) year at -20°C to -70°C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles.

Next Day 2-8°C

Mouse Monoclonal Antibody specific to Excitatory Amino Acid Transporter 1

Excitatory amino-acid transporters (EAATs), also known as glutamate transporters, belong to the family of neurotransmitter transporters. EAATs serve to terminate the excitatory signal by removal of glutamate from the neuronal synapse into neuroglia and neurons. After glutamate is released as the result of an action potential, glutamate transporters quickly remove it from the extracellular space to keep its levels low, thereby terminating the synaptic transmission. The activity of glutamate transporters also allows glutamate to be recycled for repeated release. Glutamate transporters also transport aspartate and are present in virtually all peripheral tissue. They exhibit stereoselectivity for L-glutamate but transport both L- and D-aspartate.

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:1279699, PubMed:8387171). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). {UniProtKB:O57321, UniProtKB:P56564, PubMed:1279699, PubMed:8387171}.