Anti-Fibroblast Growth Factor Receptor 1 (FGFR1) Antibody (30102)

Recombinant human ectodomain of FGFR-1b expressed in E. coli beginning with proline 23; antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences.

PBS, pH 7.4

Liquid

Purified by Protein G affinity chromatography

These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Next Day 2-8°C

Mouse Monoclonal Antibody specific to both α (denatured) and β isoforms of FGF Receptor 1. Epitope is within the sequence his241 and val267 between Ig loops II and III. Epitope is masked in undenatured FGFr1α.

The fibroblast growth factor (FGF) family is a group of multi-functional polypeptides that function in embryonic development, tissue repair, neuronal cell survival, cardiovascular disease, and tumorigenesis. The biological activities of FGF are mediated by cell surface receptors that have tyrosine kinase activity. FGFR-1 is activated by FGF-1 and FGF-2. In neoplastic cells, overexpression of FGF-1, FGF-2 and FGF receptors appear to contribute to cellular trans- formation and proliferation.

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {UniProtKB:P16092, PubMed:10830168, PubMed:11353842, PubMed:12181353, PubMed:1379697, PubMed:1379698, PubMed:15117958, PubMed:16597617, PubMed:17311277, PubMed:17623664, PubMed:18480409, PubMed:19224897, PubMed:19261810, PubMed:19665973, PubMed:20133753, PubMed:20139426, PubMed:21765395, PubMed:8622701, PubMed:8663044}.

Xu et al. (1992) J Biol Chem 267: 17792
Wang et al. (1995) J Biol Chem 270: 10231
Myoken et al. (1996) J Pathol 178: 429
Kong, S., Cao, Y. (2020), et al. Cell Mol Med. 24(8):4677-4686
FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages. J Neuroinflammation (2020) [32867781]