Anti-Hemoglobin [Clone HB11-203.1]

Purified human hemoglobin

This monoclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.2 - 7.4 with no carrier protein or preservatives added.

Liquid

Antibodies are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

This antibody is stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Next Day 2-8°C

These antibodies recognize human hemoglobin. They do not cross-react with hemoglobin of the following species: bovine, chicken, equine, ovine, or porcine.

High-Affinity Total Hemoglobin Detection in Immunoassay Development

Hemoglobin is the primary iron-containing, oxygen-transport metalloprotein found in vertebrate red blood cells (RBCs), making up approximately 35% of total mammalian erythrocyte content. Structurally, the mammalian hemoglobin tetramer is highly optimized for gaseous exchange, binding up to four oxygen molecules with an oxygen-binding capacity of 1.34 mL O₂ per gram. Beyond systemic oxygen delivery, hemoglobin is vital for transporting respiratory carbon dioxide (as carbaminohemoglobin) and managing vascular tone through nitric oxide binding. Emerging research has also mapped hemoglobin expression to non-erythroid tissues—including A9 dopaminergic neurons in the substantia nigra, macrophages, alveolar cells, and renal mesangial cells—where it functions as a critical cellular antioxidant and a regulator of cellular iron metabolism.

Leinco Technologies' (Formally QED Biosciences) Anti-Hemoglobin Monoclonal Antibody (Clone HB11-203.1 / SKU 19002) is a highly specific mouse IgG1 engineered for robust human hemoglobin detection. Developed against purified human hemoglobin, this clone exhibits exceptional target binding affinity with zero cross-reactivity to bovine, equine, porcine, chicken, or ovine hemoglobin variants. Because it targets a highly stable total-hemoglobin epitope, Clone HB11-203.1 serves as an ideal capture or detection tool in quantitative immunoassay platforms, including sandwich ELISAs, Western blotting (WB), and lateral flow assay development. Whether you are developing in vitro diagnostic (IVD) tools for metabolic disorders, clinical colorectal cancer screening (fecal occult blood testing), or researching non-oxygen-carrying hemoglobin functions in specialized tissues, Leinco’s premium manufactured primary antibodies deliver the batch-to-batch consistency, high purity, and reliability required for world-class publications.