Name: Anti-Human HER2/neu [Clone G002.1]
SKU: 34061
Price: 175.00 USD
Availability: InStock

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Anti-Human HER2/neu [Clone G002.1]

Product No.: 34061


Clone G002.1 Target Her2/Neu Formats AvailableView All Product Type Monoclonal Alternate Names EC 2.7.10.1, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD antigen CD340 Isotype Mouse IgG2a Applications IHC


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Data

Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Detection of Her2/Neu in human breast carcinoma with #34061 diluted 1:100-1:200.

Antibody Details

Product Details

Reactive Species

Human

Host Species

Mouse

Immunogen

Recombinant human Her2/Neu.

Product Concentration

Lot Specific

Formulation

Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.

State of Matter

Liquid

Product Preparation

Purified by immunoaffinity chromatography

Storage and Handling

Store at 2-8°C. Do not freeze.

Country of Origin

USA

Shipping

Next Day 2-8°C

Applications and Recommended Usage?
Quality Tested by Leinco

Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Mouse Monoclonal Antibody specific to Her2/Neu

Background

The Her2/Neu (c-erB-2) proto-oncogene product is a trans-membrane receptor tyrosine kinase that is clinically indicated in a number of carcinomas. Overexpression of the Her2/Neu protein has been associated with ductal breast cancer as well as with pulmonary and gastric adenocarcinomas. A correlation between Her2/Neu and p53 has also been reported as overexpression of both proteins has been associated with early invasion and metastasis in bladder cancer.

Function

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {PubMed:10358079, PubMed:15380516, PubMed:21555369}.

NCBI Gene Bank ID

ERBB2

UniProt.org

P04626

Research Area

Cancer Research