Anti-Human Activating Transcription Factor 6 (CT) (ATF6)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human Activating Transcription Factor 6 (CT) (ATF6)

Pricing & Details

Product No.A271
Protein
ATF6
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Activating Transcription Factor 6
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
A271-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
A271-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:A275
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Activating Transcription Factor 6 (ATF6) recognizes an epitope near the C-terminus of Human and Mouse ATF6. This polyclonal antibody was purified using affinity chromatography.
Background
Disruptions of protein folding and maturation in the endoplasmic reticulum (ER) result in the activation of the unfolded protein response (UPR), an integrated cellular signaling pathway that transmits information from the ER lumen to the cytoplasm and nucleus. Activating transcription factor 6 (ATF6) as well as the ER-transmembrane protein kinases IRE1p and PERK are the major transducers of the UPR . ATF6 is an ER transmembrane protein that is normally bound to the ER chaperone GRP78, but upon ER stress is released from GRP78 and proteolytically cleaved to yield a cytosolic fragment which then migrates to the nucleus, and together with the transcription factor XBP-1, activates transcription of UPR-responsive genes.2-4 ATF6 has two isoforms (ATF6Α and ATF6Β); only ATF6Α is recognized by this antibody.

Antigen Details

Protein
PubMed

References & Citations

1. Liu, CY. et al. (2003) J Cell Sci. 116(Pt 10):1861-2.
2. Haze, K. et al. (1999) Mol. Cell. Biol. 10:3787
3. Little, E. et al. (1994) Crit. Rev. Eukaryot. Gene Expr. 4:1
4. Yoshida, H. et al. (2001) Cell 107:881
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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