Anti-Human Apoptosis Antagonizing Transcription Factor (AATF)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human Apoptosis Antagonizing Transcription Factor (AATF)

Pricing & Details

Product No.A239
Protein
Apoptosis Antagonizing Transcription Factor
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Che-1, DED
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
A239-20 µg
20 µg
$95.00
In stock
Max:
Min: 1
Step: 1
A239-0.1 mg
0.1 mg
$440.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:A240
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at – 20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human AATF recognizes human and mouse Apoptosis Antagonizing Transcription Factor (AATF). This polyclonal antibody was purified using affinity chromatography.
Background
AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK) (1), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases (2). AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways (3). Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the b-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer’s disease (AD) (4,5), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.

Antigen Details

References & Citations

1. Page, G. et al. (1999) FEBS Lett. 462:187-191.
2. Kawai, T. et al. (1998) Mol. Cell Biol. 18:1642-51.
3. Lindfors, K. et al. (2000) Biochem. Biophys. Res. Commun. 276:660-6.
4. Xie, J. and Guo, Q. (2004) Neurobiol. of Dis. 16:150-7.
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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