Anti-Human ARMER (CT)

Pricing & Details

Product No.A249
Protein
ARMER
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
ARL6IP, AIP1
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
A249-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
A249-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:A263
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human ARMER recognizes an epitope near the C-terminus of human and mouse ARMER. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA.1 Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12,2 other caspases such as caspase-9 are also thought to be activated following ER stress.3 Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity,3 although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Antigen Details

Protein
PubMed

References & Citations

1. Stellar, H. (1995) Science 267:1445-9.
2. Nakagawa, T. et al. (2000) Nature 403:98-103.
3. Lui, HM. et al. (2003) Mol. Cancer Res. 1:508-18.
IHC
General Western Blot Protocol
Prod No.
Description
A263
A249
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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