Anti-Human Autophagy protein 7 (NT) (APG7)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human Autophagy protein 7 (NT) (APG7)

Pricing & Details

Product No.A248
Protein
APG7
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Autophagy Protein 7, ATG7
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
A248-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
A248-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:A260
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Autophagy protein 7 (NT) (APG7) recognizes an epitope near the N-terminus of human and mouse APG7. This polyclonal antibody was purified using affinity chromatography.
Background
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components.1,2 This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1.3 Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog.4 In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles.5 It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death.6

Antigen Details

Protein
PubMed

References & Citations

1. Gozuacik, D. and Kimchi, A. (2004) Oncogene. 23:2891-906.
2. Kisen, GO. et al. (1993) Carcinogenesis 14:2501-5.
3. Kamada, Y. et al. (2000) J. Cell. Biol. 150:1507-13.
4. Mizushima, N. et al. (1998) Nature 395:395-8.
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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