Anti-Human Beclin-1 (CT)

Pricing & Details

Product No.B451
Protein
Beclin-1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Coiled-coil myosin-like Bcl-2-interacting protein
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
B451-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
B451-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:B482
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Beclin-1 recognizes an epitope near the C-terminus of human and mouse Beclin-1. This polyclonal antibody was purified using affinity chromatography.
Background
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells.1,2 Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6,3,4 is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors.5 Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death.6

Antigen Details

Protein
PubMed

References & Citations

1. Gozuacik D and Kimchi A. (2004) Oncogene. 23:2891-906.
2. Kisen, GO. et al. (1993) Carcinogenesis 14:2501-5.
3. Liang, XH. et al. (1998) J. Virol. 72:8586-96.
4. Kametaka, S. et al. (1998) J. Biol. Chem. 273:22284-91.
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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