Anti-Human CARD8

Pricing & Details

Product No.C1216
Protein
CARD8
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Caspase Recruitment Domain Family Member 8, Cardinal, TUCAN
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1216-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
C1216-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:C1228
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Caspase Recruitment Domain Family Member 8 (CARD8) recognizes Human CARD8. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis,1,2 and caspase-1 and its related proteins ICEBERG and pesudo-ICE.3 Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein,2,4 it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-κB activation.

Antigen Details

Protein
PubMed

References & Citations

1. Scholl, FA. et al. (2000) J. Cell Biol. 151:495-506.
2. Stilo, R. et al. (2002) FEBS Lett. 521(1-3):165-9.
3. Razmara, M. et al. (2002) J. Biol. Chem. 277:13952-8.
4. Pathan, N. et al. (2001) J. Biol. Chem. 276:32220-9.
General Western Blot Protocol
Prod No.
Description
C1228
C1216
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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