Anti-Human CARMA1

Pricing & Details

Prod. No.C1217
Clone
Product Type
Polyclonal Antibody
Alternate Names
Isotype
Rabbit
Workshops
Size
Price
Add to cart
20 µg
195.00
Max:
Min: 1
Step: 1
0.1 mg
397.00
Max:
Min: 1
Step: 1

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:C1231
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human CARMA1 recognizes an epitope near the C-terminus of human and mouse CARMA1. This polyclonal antibody was purified using affinity chromatography.
Background
CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules.1 CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types.2,3 Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I/K complex, thereby regulating activation of the NF-κB transcription factor.5 Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.6

Antigen Details

Protein
PubMed

References & Citations

1. Fanning, AS. and Anderson, JM. (1999) Curr. Opin. Cell Biol. 11:432-9.
2. Gaide, O. et al. (2001) FEBS Lett. 496:121-7.
3. Bertin, J. et al. (2001) J. Biol. Chem. 276:11877-82.
4. McAllister-Lucas, LM. et al. (2001) J. Biol. Chem. 276:30589-97.
General Western Blot Protocol
Prod No.
Description
C1231
C1217
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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