Anti-Human Caspase-3 [Clone C31.129] — Alexa Fluor® 647
Anti-Human Caspase-3 [Clone C31.129] — Alexa Fluor® 647
Product No.: C1772
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Clone C31.129 Target Caspase-3 Formats AvailableView All Product Type Hybridoma Monoclonal Antibody Alternate Names Caspase 3 preproprotein, Casp3, cpp32, Apopain, Yama, PARP cleavage protease, SREBP cleavage activity 1 Isotype Mouse IgG1 Applications FC |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Purified Recombinant Human CASP3 (>98%) Product Concentration 0.2 mg/ml Formulation This Alexa Fluor® 647 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Alexa Fluor® is a trademark of Life Technologies Corporation. State of Matter Liquid Storage and Handling This Alexa Fluor® 647 conjugate is stable when stored at 2-8°C. Do not freeze. Regulatory Status Research Use Only Country of Origin USA Shipping 2-8°C Wet Ice Excitation Laser Red Laser (633 nm) Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm. RRIDAB_2828838 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Mouse Anti-Human Caspase-3 Active Subunit (p17) (CASP3) (Clone C31.129) recognizes an epitope on Human CASP3. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background Caspase-3 is a member of the caspase family of cysteine proteases and plays a key role in mediating Fas (CD95) and tumor necrosis factor–1 (TNFR-1) induced apoptosis. Caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators.1,2 Caspase-3 is activated during apoptotic signaling events by upstream proteases including caspase 6 and caspase 8.3 Caspase-3 is thought to be essential for chromatin margination, DNA fragmentation and nuclear collapse during apoptosis.3 PubMed NCBI Gene Bank ID UniProt.org References & Citations1. Adadah, BA. et al. (2000) Journal of Neurotoma 17(10): 811 2. Salvesen, GS. et al. (1999) Proc. Natl. Acad. Sci. USA 96(20): 10964 3. Slee, EA. et al. (2001) J. Biol. Chem. 276(10):7320 Technical Protocols Certificate of Analysis |
Formats Available
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Prod No. | Description |
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C1768 | |
C1769 | |
C1770 | |
C1774 | |
C1772 | |
C1768AF | |
C1141 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
