Anti-Human Caspase-8 Active Subunit (p18)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human Caspase-8 Active Subunit (p18)

Pricing & Details

Product No.C1142
Clone
C81.349
Protein
Caspase-8 Active Subunit (p18)
Formats AvailableView All
Product Type
Monoclonal Antibody
Isotype
Mouse
IgG2b
Applications
ELISA Cap
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1142-0.2 mg
0.2 mg
$277.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Product Concentration
0.5 mg/ml
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Anti-Human Caspase-8 Active Subunit (p18) (clone C81.349) recognizes the human 18-20 kDa cleaved active subunit of caspase 8 and does not react with the inactive proenzyme. The antibody was developed using a synthetic peptide with residues mapping to the N-terminus of the (p18) subunit of human caspase 8.
Background
Caspase-8 is a member of the caspase family of cysteine proteases and plays a key role in mediating Fas (CD95) and tumor necrosis factor–1 (TNFR-1) induced apoptosis. Activation of caspase 8 by proteolytic cleavage leads to the release of the active p18 and p10 subunits. These processed subunits associate to form an active enzyme.

Antigen Details

Research Area
Apoptosis
.
Cell Biology
.
Immunology

References & Citations

1. Muzio, M. et al. (1996) Cell 85: 817
2. Boldin, MP. et al. (1996) Cell 85: 803
3. Fernandes-Alnemri, T. et al. (1996) Proc. Natl. Acad. Sci. USA 93:7464
Elisa Sandwich Protocol
General Western Blot Protocol

Formats Available

Prod No.
Description
C1142
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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