Anti-Human Caspase-8 Active Subunit (p18)
Anti-Human Caspase-8 Active Subunit (p18)
Product No.: C1142
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Clone C81.349 Target Caspase-8 Active Subunit (p18) Formats AvailableView All Product Type Monoclonal Antibody Isotype IgG2b Applications ELISA Cap , WB |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Product Concentration 0.5 mg/ml Formulation This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This purified antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2828344 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Anti-Human Caspase-8 Active Subunit (p18) (clone C81.349) recognizes the human 18-20 kDa cleaved active subunit of caspase 8 and does not react with the inactive proenzyme. The antibody was developed using a synthetic peptide with residues mapping to the N-terminus of the (p18) subunit of human caspase 8. Background Caspase-8 is a member of the caspase family of cysteine proteases and plays a key role in mediating Fas (CD95) and tumor necrosis factor–1 (TNFR-1) induced apoptosis. Activation of caspase 8 by proteolytic cleavage leads to the release of the active p18 and p10 subunits. These processed subunits associate to form an active enzyme. Research Area Apoptosis . Cell Biology . Immunology References & Citations1. Muzio, M. et al. (1996) Cell 85: 817 2. Boldin, MP. et al. (1996) Cell 85: 803 3. Fernandes-Alnemri, T. et al. (1996) Proc. Natl. Acad. Sci. USA 93:7464 Technical Protocols  Certificate of Analysis |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
