Anti-Human CD11c (Clone 118/A5) – Purified

Anti-Human CD11c (Clone 118/A5) – Purified

Product No.: C881

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Clone
118/A5
Target
CD11c
Formats AvailableView All
Product Type
Hybridoma Monoclonal Antibody
Alternate Names
CD11c, 118/A5
Isotype
Mouse IgG2b κ
Applications
IF
,
IHC

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Immunogen
Synthetic peptide conjugated to KLH corresponding to the C-terminus of human CD11c: ANGQIAPENGTQTPSPPSEK
Product Concentration
0.5 mg/ml
Formulation
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
State of Matter
Liquid
Storage and Handling
This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Regulatory Status
Research Use Only
Country of Origin
USA
Shipping
2 – 8° C Wet Ice
Additional Applications Reported In Literature ?
IHC
IF
FC
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Human CD11c
Background
CD11c (also known as ITGAX) is a member of the leukointegrin family that binds to iC3b, fibrinogen, VCAM-1, ICAM-1, ICAM-2 1, and ICAM-4 2. CD11c is involved in phagocytosis, cell migration, cytokine production by monocytes/macrophages, induction of T cell proliferation by Langerhans cells 1, monocyte adhesion 3, chemotaxis, host defense 4and tissue homeostasis. CD11c combines with ITGB2 (beta 2 chain) to form inactivated-C3b receptor 4 (CR4) 5 and is widely used as a marker for dendritic cells 6. CD11c expression is significantly higher in patients with gastric cancer than gastritis or gastric polyps, and increases during cancer stage progression, suggesting an involvement in gastric cancer pathology 7. Additionally, CD11c may play a role in the functional mechanism of anti-CD47 cancer immunotherapy 6. CD11c also mediates cell-cell interaction during the inflammatory response 3, and CD11c+ T-bet+ IgM memory cells are generated during bacterial infection and are important for long-term immunity during chronic infections and diseases 8. CD11c is also associated with cognitive decline 9. The 118/A5 antibody does not cross-react with rhesus macaque CD11c 10.
Antigen Distribution
CD11c is expressed on tissue macrophages and dendritic cells. Expression has also been observed on natural killer cells, some activated B and T cells, professional phagocytes, and microglia. CD11c is overexpressed in myeloid- and monocyte-associated dendritic cells.
NCBI Gene Bank ID
UniProt.org

References & Citations

1. Sadhu C, Ting HJ, Lipsky B, et al. J Leukoc Biol. 81(6):1395-1403. 2007.
2. Ihanus E, Uotila LM, Toivanen A, et al. Blood. 109(2):802-810. 2007.
3. https://www.uniprot.org/uniprotkb/P20702/entry
4. Torres-Gomez A, Cabañas C, Lafuente EM. Front Immunol. 11:738. 2020.
5. https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=DetailsSearch&Term=3687#gene-expression
6. Wu J, Wu H, An J, et al. Proc Natl Acad Sci U S A. 115(26):6786-6791. 2018.
7. Wang Y, Xu B, Hu WW, et al. World J Gastroenterol. 21(31):9403-9412. 2015.
8. Winslow GM, Papillion AM, Kenderes KJ, et al. Cell Immunol. 321:8-17. 2017.
9. Lopes KP, Yu L, Shen X, et al. Alzheimers Dement. Sep 19. doi: 10.1002/alz.13474. 2023.
10. Cheng Y, Burrack RK, Li Q. J Histochem Cytochem. 70(8):571-581. 2022.
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.