Anti-Human CD56 (NCAM) (Clone ERIC-1) – DyLight® 550

Anti-Human CD56 (NCAM) (Clone ERIC-1) – DyLight® 550

Product No.: C1806

[product_table name="All Top" skus="C1806"]

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Clone
ERIC-1
Target
CD56
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
NCAM, Neural cell adhesion molecule, NKH1, Leu-19
Isotype
IgG1
Applications
IHC

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Product Size
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Immunogen
Purified Recombinant Human CD56 (>98%)
Product Concentration
0.2 mg/ml
Formulation
This DyLight® 550 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This DyLight® 550 conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Excitation Laser
Yellow Laser (563 nm)
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human CD56 (Clone ERIC-1) recognizes an epitope on Human CD56. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution
The CD56 (NCAM) antigen is expressed on most neuroectodermal derived cell lines, tissues, and tumors. NCAM is also known to be expressed on some mesodermally derived tissues such as muscle1 and on natural killer (NK) lymphocytes. The binding of ERIC-1 to both normal and neoplastic tissue is lost when tissues are conventionally fixed in formalin and embedded in paraffin. The epitope was preserved when exposed to dehydrating fixatives such as cold acetone (-20°C) for 5 min. CD56 is present on 10-25% of peripheral blood lymphocytes.
Background
Anti-Human CD56 can be used in studies of the neural cell adhesion molecule. This antibody may also be used to study isoforms of NCAM expressed on different tumor types. Anti-CD56 (clone ERIC-1) works well in western blot for analysis of isoforms expressed. Anti-CD56 did not react with any of the leukemias or lymphomas tested.1

Antigen Details

Ligand/Receptor
Heparan sulfate
PubMed
NCBI Gene Bank ID

References & Citations

1. Bourne, K. et al. (1991) J. of Neuro-Oncology 10:111
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.