Anti-Human Chk2 (NT)

Pricing & Details

Product No.C1124
Protein
Chk2
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Checkpoint Kinase 2
Applications
ELISA Cap
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1124-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
C1124-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:C1135
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Chk2 recognizes an epitope near the amino terminus of human, mouse and rat Chk2. This polyclonal antibody was purified using affinity chromatography.
Background
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The checkpoint kinase Chk2 is the mammalian homologue of yeast Cds1/Rad53. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 (7,8). Chk2 serves as ATM downstream effector to mediate activation of p53. Chk2 also phosphorylates and activates BRCA1, the product of a tumor suppressor gene that is mutated in breast and ovarian cancer (9).

Antigen Details

Protein
PubMed

References & Citations

1. Matsuoka, S. et al. (1998) Science. 282:1893-7.
2. Tanaka, H. et al. (2000) Nature. 404:42-9.
3. Oda, E. et al. (2000) Science. 288(5468):1053-8.
4. Oda, K. et al. (2000) Cell. 102(6):849-62.
Elisa Sandwich Protocol
General Western Blot Protocol
Prod No.
Description
C1135
C1124
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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