Name: Anti-Human Collagen Type IV [Clone G549.1]
SKU: 34056
Price: 150.00 USD
Availability: InStock

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Anti-Human Collagen Type IV [Clone G549.1]

Product No.: 34056


Clone G549.1 Target Collagen Type IV Formats AvailableView All Product Type Monoclonal Isotype Mouse IgG1 Applications IHC


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Data

Immunohistochemistry: Detection of Collagen Type IV in human lung with #34056 diluted 1:100-1:200.

Antibody Details

Product Details

Reactive Species

Human

Host Species

Mouse

Immunogen

Recombinant human Collagen Type IV.

Formulation

Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.

State of Matter

Liquid

Product Preparation

Purified by immunoaffinity chromatography

Storage and Handling

Store at 2-8°C. Do not freeze.

Shipping

Next Day 2-8°C

Applications and Recommended Usage?
Quality Tested by Leinco

Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Mouse Monoclonal Antibody specific to Collagen Type IV

Background

Type IV collagen is the main collagen component of the basement membrane. It is a network- forming collagen that underlies epithelial and endothelial cells and functions as a barrier between tissue compartments. Each type IV collagen molecule is a heterotrimer composed of three alpha chains. Type IV collagen triple helices form open, nonfibrillar networks that associate with laminin assemblies.

Function

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. {UniProtKB:P02463}.; Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. {PubMed:10811134, PubMed:18775695}.

NCBI Gene Bank ID

COL4A1

UniProt.org

P02462

Research Area

Cancer Research