Anti-Human Daxx (CT)

Anti-Human Daxx (CT)

Product No.: D259

[product_table name="All Top" skus="D259"]

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Target
Daxx
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB

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Select Product Size

Data

D259 Western Blot
D259 IHC DAXX
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:D262
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Rabbit Anti-Human Daxx recognizes an epitope near the C-terminus of mouse and human Daxx. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
PubMed

References & Citations

1. Yang, X. et al. (1997) Cell 89:1067-1076
2. Kiriakidou, M. et al. (1997) DNA Cell Biol 16:1289-98
IHC FFPE
General Western Blot Protocol

Certificate of Analysis

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Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.