Anti-Human DC-SIGN (ED)

PN:D289

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human DC-SIGN recognizes an epitope in the extracellular domain of Human DC-SIGN. This polyclonal antibody was purified using affinity chromatography.

Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes,¹ where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN.² ICAM-3 is the natural ligand for DC-SIGN.³ A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently.⁴ DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

1. Geijtenbeek, T. B. et al. (2000) Cell 100:587 2. Pohlmann, S. et al. (2001) J. Virol. 75(10):4664 3. Geijtenbeek, T. B. et al. (2000) Cell 100(5):575 4. Soilleux, E. J. et al. (2000) J. Immunol. 165(6):2937