Anti-Human DC-SIGN (ED)

Pricing & Details

Product No.D288
Protein
DC-SIGN
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
D288-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
D288-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:D289
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human DC-SIGN recognizes an epitope in the extracellular domain of Human DC-SIGN. This polyclonal antibody was purified using affinity chromatography.
Background
Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes,1 where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN.2 ICAM-3 is the natural ligand for DC-SIGN.3 A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently.4 DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Antigen Details

Protein
PubMed

References & Citations

1. Geijtenbeek, T. B. et al. (2000) Cell 100:587 2. Pohlmann, S. et al. (2001) J. Virol. 75(10):4664 3. Geijtenbeek, T. B. et al. (2000) Cell 100(5):575 4. Soilleux, E. J. et al. (2000) J. Immunol. 165(6):2937
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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